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Our results were derived from differentially expressed genes in the hippocampus and cerebral cortex of SAMP8 mice compared to age-matched SAMR1 mice at 2, 6, and 12 months of age using cDNA microarray analysis. Luciferase reporter assays were performed to indicate that STK4 is a direct target of miRa. Here we show that c-Myc activates expression of a cluster of six miRNAs on human chromosome Recent studies show novel mechanisms regulating fibrinogen expression, as well as novel roles of fibrinogen in infection, inflammation, and cognitive disorders. We determined that miRa was present at higher levels than the other five miRNAs in the cluster. The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model. In fact, several miRs, including miRa, have been reported to regulate PIAS3 expression in other diseases, including gastric cancer, multiple myeloma and chronic lymphocytic leukemia Brock et al. This study was designed to investigate the biological functions and molecular mechanisms of the miR cluster in cholangiocarcinoma.
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